HRR (Germline) gene test focuses on 15 genes (including BRCA1 and BRCA2) associated with DNA repair mechanisms to determine the familial cause of breast, ovarian, prostate, and pancreatic cancers. It is also a predictive biomarker for PARP inhibitor therapy in these four cancer types.
HRR genes other than BRCA1/2 are essential when considering PARPi therapy.
Guidelines recommend multigene HRR (Germline) gene panel testing by NGS to increase options for the patients to be treated with PARP inhibitors and opt for other treatment regimens for better management of the disease.
SNVs/InDels & CNAs Coverage in HRR (Germline) Gene Panel
ATM
BARD1
BRCA1
BRCA2
BRIP1
CDK12
CHEK1
CHEK2
FANCL
PALB2
PPP2R2A
RAD51B
RAD51C
RAD51D
RAD54L
Benefits of HRR (Germline) Gene Panel Testing
Personalized treatment decisions
The information provided by this gene panel testing allows for personalized treatment decisions based on the genomic characteristics of the tumor. This approach improves treatment outcomes by selecting therapies that are more likely to be effective and minimizing the use of treatments that are unlikely to provide benefit.
Predicting treatment response
Patients with dHRR cancers, characterized by HRD-associated mutations, often exhibit increased sensitivity to specific treatments. By identifying these mutations through this gene panel test, oncologists can predict the patient’s potential response to these targeted therapies.
Guiding the use of PARP inhibitors
This gene panel testing helps identify patients with dHRR cancers, making them potential candidates for PARP inhibitor therapy. This targeted approach improves treatment outcomes by directing patients toward therapies that are more likely to be effective.
Clinical guidelines recommendation
This gene panel testing is recommended by clinical guidelines for screening patients who will benefit from certain types of treatment. These guidelines are evidence-based recommendations developed by field experts designed to optimize patient care
Why Choose 4baseCare's HRR (Germline) Cancer Gene Panel?
Comprehensive Analysis
Our Cancer Gene Panel thoroughly assesses clinically relevant genes, ensuring accurate and reliable results.
Advanced Technology
We utilize cutting-edge next generation sequencing technology to deliver precise and detailed genetic information.
Expert Team
Our team of experienced genetic counselors and healthcare professionals will guide you through the testing process, answer your questions, and help you understand the implications of the results.
Confidentiality and Privacy
We adhere to strict privacy protocols and maintain the confidentiality of your genetic information.
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