Solutions>TARGT CGP Kit (RUO)

TARGT Comprehensive Genomic Profiling Kit (RUO)
Tumor-Associated Drug Response by Genomic Testing

Well-validated Comprehensive Genomic Profiling Kit (RUO) developed by experts to identify the genomic alterations (single nucleotide variations (SNVs), indels, copy number variants (CNVs)) and signatures across pan-solid cancers from wide sample sources.

Delivers/Uncovers molecular insights from cancer patient’s samples by focusing on therapeutic, prognostic, and diagnostic biomarkers from a single assay, which makes it efficient and rapid.

TARGT CGP Kit (RUO) includes reagents for hybridization-based library preparation (target enrichment and library creation) which can be used even for low sample input.

4baseCare Clinical Informatics platform: OncoBench supports your data analysis and reporting needs and enables quality control. The expert customer support team helps you to set up your tests and secure your results at every step.

 

TARGT CGP Kits (RUO)

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Features & Benefits

Clinical maturation of TARGT CGP Kit (RUO) was achieved by extensive analytical and robust clinical validation for all types of genomic alterations in different solid cancer types (28+ cancer types) from different tissue sources (Solid Tissue and Liquid biopsy).

Target genomic alterations
& mutational signature

Compatible with wide variety of
samples (DNA/FFPE/Fresh Frozen
/Plasma) and low quality samples

Uniquely designed DNA-Seq
panels with 4 hotspot fusions
(ALK, ROS1, RET, MET exon 14))

Well validated, highly specific
& sensitive assay

Flexible integration with
NGS sequence

Cost & Time effective

Workflow

TARGT kits offers complete solutions by generating clinical insights from the tumor samples (including FFPE DNA, FFPE RNA, Cytology smear DNA, Tissue in RNA Later, WBC from peripheral blood)

The workflow includes major steps :

Samples
 
Nucleic Acid
Extraction
 
* Library Preparation
& TARGT Enrichment
 
Sequencing
 
* Bioinformatics analysis
using OncoBench
 
* Variant Prioritisation
& Clinical Insights

TARGT assays provide edge to the scientific/clinical community because of :

  • *Uniquely designed library preparation kits : Target the coding region of the genes with ~15 probes per genes to ensure adequate coverage for all the genes and increased efficacy for low sample inputs.
  • *Bioinformatics analysis : Well validated pipeline to identify low frequency variants and in-house developed OncoBench tool to analyze the data efficiently.
  • *Clinical Insights : Aggregating, curating, variant classification based on professional guidelines (ACMG/AMP/ASCO/ESMO) using scientific information, multiple databases and in-house developed population specific database of 3500+ pan cancer patients.


Performance Metrics

Clinical maturation of TARGT CGP Kit (RUO) was achieved by extensive analytical and robust clinical validation for all types of genomic alterations in different solid cancer types (28+ cancer types) from different tissue sources (Solid Tissue and Liquid biopsy).

Parameters Solid Biopsy Liquid Biopsy
Analytical Clinical Analytical Clinical
Specificity 100% 100% 100% 100%
Sensitivity >98% >98% >98% >95%
Accuracy 100% >98% 100% >90%
Precision 100% 100% 100% 100%
Reproducibility 100% 100% 100% 100%
Limit of Detection 5% for SNV and 10% for InDels (<10 bp) 5% for SNV and 10% for InDels (<10 bp) 1% for SNV and 5% for InDels (<10 bp) 1% for SNV and 5% for InDels (<10 bp)
PPV 100% 98% 100% 90%
NPV 100% 100% 100% 100%

OncoBench

OncoBench is a 360-degree solution that helps the user (Scientists/ Healthcare professional) to identify significant biomarkers and generate comprehensive clinical reports in a secure, time-efficient and cost-effective manner.

OncoBench_ClinicalReporting
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